THE DYNAMIN CHEMICAL INHIBITOR DYNASORE IMPAIRS CHOLESTEROL TRAFFICKING AND STEROL-SENSITIVE GENES TRANSCRIPTION IN HUMAN HELA CELLS AND MACROPHAGES.

Intracellular transport of cholesterol contributes to the regulation of cellular cholesterol homeostasis by mechanisms that are yet poorly defined.In this study, we characterized the impact of dynasore, a recently described drug that specifically inhibits the enzymatic ECINACEA LOZ activity of dynamin, a GTPase regulating receptor endocytosis and c

This article presents one possible point of view on the interregional cooperation through the optic of neorealist and Sound meters neoliberal international relation theories.Applying the constructivist approach to utility function and creating utility function of regions, the author aims to explain the reasons of difficulties of interregional coope

Leptosphaeria maculans is a hemibiotrophic fungus that causes blackleg of canola (Brassica napus), one of the most devastating diseases of this crop.In the present study, transcriptome profiling of L.maculans was performed in an effort to understand and define the pathogenicity genes that govern both the biotrophic and the necrotrophic phase of the

Abstract Long-read single-cell RNA sequencing (scRNA-seq) enables the quantification of RNA isoforms in individual cells.However, long-read scRNA-seq using the Oxford Nanopore platform has largely relied upon matched short-read data to Doors identify cell barcodes.We introduce BLAZE, which accurately and efficiently identifies 10x cell barcodes usi

Development of cost-effective Pt-based electrocatalysts is of scientific and industrial importance for hydrogen evolution from water splitting.In this work, cost-efficient Pt-based catalysts, immobilized on functionalized Vulcan Carbon (VC) from hydrothermal treatment of Ru Steel precursor and ethylene glycol solution, for hydrogen evolution reacti